Predicting Factors for Refractory Kawasaki Disease

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Predicting Factors for Refractory Kawasaki Disease

BACKGROUND AND OBJECTIVES About 10-15% of Kawasaki disease (KD) is refractory to intravenous immunoglobulin (IVIG) therapy. This study was designed to investigate the predicting factors for refractory KD. SUBJECTS AND METHODS We reviewed retrospectively the clinical records of 77 patients with typical KD admitted at Wonju Christian Hospital from January, 2005, to December, 2008. The variance ...

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Recurrent refractory Kawasaki disease

Case report A 3 year old boy presented with 3 days of fever, rash, pharyngeal and gingival erythema, and swollen extremities. Laboratory investigations revealed leukocytosis, C– reactive protein 25.8 mg/dl, and erythrocyte sedimentation rate 100 mm/hr. Echocardiography disclosed diffuse dilatation of all proximal coronary arteries. The child received IVIG (2g/kg) and aspirin (100 mg/kg/d) with ...

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Atypical Kawasaki disease presenting as refractory pneumonia.

Despite its importance, a timely diagnosis of KD is often a challenge because it still relies on non-specific clinical signs, and no definite laboratory tests have yet been identified. Diagnosis of KD can be even more difficult in patients who do not fulfill the diagnostic criteria. A clinical presentation with less than the required criteria for KD and/or unusual clinical features (“incomplete...

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Risk factors for refractory Kawasaki disease: clinical records of the paediatric clinic of palermo

Introduction Kawasaki disease (KD) is an acute, self-limited febrile illness that mainly affecting smallto medium-sized vessels and occurs in early childhood. The etiology is currently unknown, however it likely results from an immunologic response triggered by microbial agents, with documented genetic susceptibility. Intravenous administration of immunoglobulin (IVIG) is the gold standard ther...

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Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared with those without. Therefore, an anti-TNF-alphaagent (infliximab) was administered to a 1-month-old girl with refractory KD complicated by CA an...

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ژورنال

عنوان ژورنال: Korean Circulation Journal

سال: 2010

ISSN: 1738-5520

DOI: 10.4070/kcj.2010.40.5.239